Efficacy & Safety of Octaplas for Cardiac Surgery
Effects of Octaplas and FFP on hemostasis and fibrinolysis in complex coagulopathy following
- Prospective open-label study in post-operative, open heart surgery patients who required plasma transfusion for acute bleeding or for risk of bleeding
- Study was not powered to detect a difference in efficacy
|STUDY OBJECTIVES: ASSESS EFFICACY AND TOLERABILITY OF
OCTAPLAS IN PATIENTS UNDERGOING CARDIAC SURGERY
|N (Male/Female)||36 (20/16)||31 (17/14)|
|Median age (range)||69.5 years (34-79)||72 years (55-86)|
|Median dosage (range)||8.5 mL/kg (5.5-14.2)||8.5 mL/kg (5.5-12.2)|
Clinical hemostasis evaluation revealed no significant difference between Octaplas and FFP. No adverse reactions were reported.
- Haubelt H, Blome M, Kiessling AH, et al. Effects of solvent/detergent-treated plasma and fresh-frozen plasma on haemostasis and fibrinolysis in complex coagulopathy following open-heart surgery. Vox Sang 2002; 82:9-14.